USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: PSB10_HUMAN USC-OGP 2-DE database:  PSB10_HUMAN PSB10_HUMAN General information about the entry View entry in simple text format Entry name PSB10_HUMAN Primary accession number P40306 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-10; EC=3.4.25.1; AltName: Full=Low molecular mass protein 10; AltName: Full=Macropain subunit MECl-1; AltName: Full=Multicatalytic endopeptidase complex subunit MECl-1; AltName: Full=Proteasome MECl-1; AltName: Full=Proteasome subunit beta-2i; Flags: Precursor;. Gene name Name=PSMB10 Synonyms=LMP10, MECL1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0514: pI=5.98; Mw=26427 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0795: pI=5.97; Mw=29781 Cross-references UniProtKB/Swiss-Prot P40306; PSB10_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSB10_HUMAN Primary accession number P40306 Secondary accession number(s) B2R5J4 Q5U098 Sequence was last modified on  February 1, 1995 (version 1) Annotations were last modified on  March 15, 2017 (version 175) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-10; EC=3.4.25.1; AltName: Full=Low molecular mass protein 10; AltName: Full=Macropain subunit MECl-1; AltName: Full=Multicatalytic endopeptidase complex subunit MECl-1; AltName: Full=Proteasome MECl-1; AltName: Full=Proteasome subunit beta-2i; Flags: Precursor; Gene name Name=PSMB10 Synonyms=LMP10, MECL1 Encoded on Name=PSMB10; Synonyms=LMP10, MECL1 Keywords Acetylation; Complete proteome; Cytoplasm; Host-virus interaction; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X71874; CAA50709.1; -; Genomic_DNA EMBL Y13640; CAA73982.1; -; mRNA EMBL BT019723; AAV38528.1; -; mRNA EMBL BT019724; AAV38529.1; -; mRNA EMBL AK312208; BAG35141.1; -; mRNA EMBL CH471092; EAW83187.1; -; Genomic_DNA EMBL BC017198; AAH17198.1; -; mRNA EMBL BC052369; AAH52369.1; -; mRNA CCDS CCDS10853.1; -; . PIR I38135; I38135; . RefSeq NP_002792.1; NM_002801.3; . UniGene Hs.9661; -; . ProteinModelPortal P40306; -; . SMR P40306; -; . BioGrid 111672; 23; . IntAct P40306; 11; . STRING 9606.ENSP00000351314; -; . BindingDB P40306; -; . ChEMBL CHEMBL3317334; -; . DrugBank DB08889; Carfilzomib; . MEROPS T01.014; -; . iPTMnet P40306; -; . PhosphoSitePlus P40306; -; . BioMuta PSMB10; -; . DMDM 730376; -; . OGP P40306; -; . SWISS-2DPAGE P40306; -; . EPD P40306; -; . MaxQB P40306; -; . PaxDb P40306; -; . PeptideAtlas P40306; -; . PRIDE P40306; -; . DNASU 5699; -; . Ensembl ENST00000358514; ENSP00000351314; ENSG00000205220; . GeneID 5699; -; . KEGG hsa:5699; -; . UCSC uc002eux.3; human; . CTD 5699; -; . DisGeNET 5699; -; . GeneCards PSMB10; -; . HGNC HGNC:9538; PSMB10; . HPA CAB034384; -; . HPA HPA030224; -; . HPA HPA030225; -; . MIM 176847; gene; . neXtProt NX_P40306; -; . OpenTargets ENSG00000205220; -; . PharmGKB PA33883; -; . eggNOG KOG0173; Eukaryota; . eggNOG COG0638; LUCA; . GeneTree ENSGT00510000046533; -; . HOGENOM HOG000182856; -; . HOVERGEN HBG093416; -; . InParanoid P40306; -; . KO K02733; -; . OMA QTLFRYR; -; . OrthoDB EOG091G0E5S; -; . PhylomeDB P40306; -; . TreeFam TF106222; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMB10; human; . GeneWiki PSMB10; -; . GenomeRNAi 5699; -; . PRO PR:P40306; -; . Proteomes UP000005640; Chromosome 16; . Bgee ENSG00000205220; -; . CleanEx HS_PSMB10; -; . ExpressionAtlas P40306; baseline and differential; . Genevisible P40306; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0000502; C:proteasome complex; TAS:ProtInc; . GO GO:0005839; C:proteasome core complex; ISS:UniProtKB; . GO GO:1990111; C:spermatoproteasome complex; ISS:UniProtKB; . GO GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0006959; P:humoral immune response; TAS:ProtInc; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 3.60.20.10; -; 1; . InterPro IPR029055; Ntn_hydrolases_N; . InterPro IPR000243; Pept_T1A_subB; . InterPro IPR024689; Proteasome_bsu_C; . InterPro IPR016050; Proteasome_bsu_CS; . InterPro IPR001353; Proteasome_sua/b; . InterPro IPR023333; Proteasome_suB-type; . Pfam PF12465; Pr_beta_C; 1; . Pfam PF00227; Proteasome; 1; . PRINTS PR00141; PROTEASOME; . SUPFAM SSF56235; SSF56235; 1; . PROSITE PS00854; PROTEASOME_BETA_1; 1; . PROSITE PS51476; PROTEASOME_BETA_2; 1; .

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